Genetics play a key role in fertility and the success of a pregnancy. Chromosomal anomalies are a crucial factor to consider when natural conception or treatments like Intrauterine Insemination (IUI) have not been successful. But what exactly are these anomalies, and how can they affect your chances of achieving a healthy pregnancy? Read on to learn more!
What are Chromosomal Anomalies?
These occur when there are changes in the number or structure of chromosomes, leading to two main types:
- Numerical Anomalies:
- Trisomies (extra chromosomes): For instance, Down syndrome (Trisomy 21).
- Monosomies (missing chromosomes): Like Turner syndrome, where one X chromosome is absent.
- Structural Anomalies:
- Deletions: Missing fragments of a chromosome.
- Translocations: Chromosomal fragments relocate to another chromosome.
Anomalies can be inherited or arise spontaneously during egg or sperm formation.
Why genetics matter in fertility
Chromosomal anomalies are a leading cause of:
- Miscarriages, particularly in the first trimester.
- Failed Assisted Reproduction Treatments, including IVF, where embryos with genetic abnormalities are less likely to implant or develop.
Advanced tools like genetic testing and embryo screening are often used to improve success rates.
What genetic tests are available?
Modern techniques can evaluate both parents and embryos for anomalies:
- For Parents:
- Karyotype Analysis: Examines chromosome structure and number.
- Carrier Panels: Detects specific genetic mutations.
- For Embryos (during Assisted Reproduction):
- PGT-A (Preimplantation Genetic Testing for Aneuploidies): Screens for chromosomal abnormalities before embryo transfer.
- PGT-M (Preimplantation Genetic Testing for Monogenic Diseases): Detects specific genetic mutations linked to conditions.
Nascere’s approach
At Nascere, genetic testing is integral to our IVF protocols. Using state-of-the-art technology and specialized labs, we ensure only the healthiest embryos are selected, improving treatment outcomes.
- Success Rates:
- With genetic testing: Implantation rates can reach 60-70%.
- Without genetic testing: Success rates vary between 30-40%, depending on age and embryo quality.
Testing not only boosts pregnancy chances but also reduces miscarriage risks tied to genetic issues.
Some conditions that we screen for
Common chromosomal conditions that could pose pregnancy risks include:
- Down Syndrome (Trisomy 21): Linked to developmental delays and intellectual disability.
- Edwards Syndrome (Trisomy 18): Associated with severe malformations and limited life expectancy.
- Patau Syndrome (Trisomy 13): Related to serious physical abnormalities.
- Turner Syndrome (Monosomy X): Impacts sexual development and fertility in females.
If you have a family history of genetic conditions, sharing that information with our team allows us to tailor your treatment and verify embryo health.
Your family dream is within reach
If you’re exploring fertility treatments, genetic testing and embryo selection can help ensure your baby has the best chance of a healthy start.
At Nascere, we have the expertise and cutting-edge technology to guide you every step of the way. Schedule your consultation today and take the first step toward your future!